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Transcriptomics-driven metabolic pathway analysis reveals similar alterations in lipid metabolism in mouse MASH model and human.

Sofia TsoukaPavitra KumarPatcharamon SeubnoochKatrin FreiburghausMarie St-PierreJean-François DufourMojgan Masoodi
Published in: Communications medicine (2024)
We introduce TDMPA, a methodology for evaluating metabolic pathway alterations in metabolic disorders. By comparing metabolic signatures that typify human MASH, we show a good metabolic resemblance of the WD+CCl4 mouse model. Our presented approach provides a valuable tool for defining metabolic space to aid experimental design for assessing metabolism.
Keyphrases
  • mouse model
  • single cell
  • gene expression
  • induced pluripotent stem cells
  • fatty acid