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Effect of Bovine Lactoferrin Treatment on Iron Homeostasis and Gene Expression Changes in Multiple Organ Dysfunctions During Wound Healing Process in Rats.

Ahmet Sarper BozkurtŞenay Görücü Yılmaz
Published in: Current gene therapy (2024)
In the organ-level ferroptotic damage mechanism triggered by wound formation. BLf controls the expression of three genes and manages iron deposition in these three tissues. In addition, it suppressed the increase in iron that would drive the cell to ferroptosis and anemia caused by inflammation, thereby eliminating iron deposition in the tissues.
Keyphrases
  • iron deficiency
  • gene expression
  • wound healing
  • oxidative stress
  • dna methylation
  • poor prognosis
  • cell death
  • chronic kidney disease
  • binding protein
  • replacement therapy
  • smoking cessation