Whole-transcriptome changes in gene expression accompany aging of sensory neurons in Aplysia californica.
Justin B GreerMichael C SchmaleLynne A FieberPublished in: BMC genomics (2018)
Significantly altered expression of many genes between sexually mature and aged Aplysia suggests large molecular changes that may impact neuronal function. Decreased ion channel mRNA observed could mean fewer receptors present in aged neurons, resulting in reduced excitability of PVC sensory neurons, ultimately leading to reduced tail-withdrawal reflex observed in aged Aplysia. Significant changes in other genes and pathways, such as stress response and learning and memory, have previously been shown to occur with age in many vertebrate organisms. This suggests that some effects of aging are common across many animal phyla.
Keyphrases
- gene expression
- genome wide
- spinal cord
- dna methylation
- poor prognosis
- bioinformatics analysis
- genome wide identification
- binding protein
- single cell
- rna seq
- spinal cord injury
- long non coding rna
- transcranial direct current stimulation
- blood brain barrier
- transcription factor
- single molecule
- subarachnoid hemorrhage