DNA copy number alterations, gene expression changes and disease-free survival in patients with colorectal cancer: a 10 year follow-up.
Elisabetta BigagliCarlotta De FilippoCinzia CastagniniSimona TotiFrancesco AcquadroFrancesco GiudiciMarilena FaziPiero DolaraLuca MesseriniFrancesco TonelliCristina LuceriPublished in: Cellular oncology (Dordrecht) (2016)
Our results suggest that CNAs in CRC tumor tissues are associated with concomitant changes in the expression of cancer-related genes. In other genes epigenetic mechanism may be at work. Up-regulation of the IL17RA, IGF2BP2 and ABCC2 genes, and of genes acting in the mTOR and cytokine receptor pathways, appear to be associated with a poor survival. These alterations may, in addition to Dukes' staging, be employed as new prognostic biomarkers for the prediction of clinical outcome in CRC patients.
Keyphrases
- genome wide
- gene expression
- copy number
- free survival
- dna methylation
- mitochondrial dna
- end stage renal disease
- bioinformatics analysis
- genome wide identification
- ejection fraction
- chronic kidney disease
- newly diagnosed
- poor prognosis
- binding protein
- papillary thyroid
- rheumatoid arthritis
- peritoneal dialysis
- cell proliferation
- systemic lupus erythematosus
- squamous cell carcinoma
- cell free
- patient reported outcomes
- ankylosing spondylitis
- signaling pathway
- disease activity
- patient reported
- pi k akt