Low-dose decitabine promotes M2 macrophage polarization in patients with primary immune thrombocytopenia via enhancing KLF4 binding to PPARγ promoter.

Xia ShaoPengcheng XuLili JiBoting WuYanxia ZhanXibing ZhuangYang OuFanli HuaLihua SunFeng LiXiangdong WangHao Chen Yunfeng Cheng

Published in: Clinical and translational medicine (2023)

Low-dose DAC promoted M2 macrophage polarization due to the demethylation within the promoter of PPARγ, thus enhanced the KLF4 binding affinity in ITP.

Keyphrases

low dose
transcription factor
dna methylation
high dose
dna binding
insulin resistance
gene expression
acute myeloid leukemia
fatty acid
binding protein
mass spectrometry