The Mononuclear Phagocyte System of the Rat.
David A HumeMelanie CarusoSahar KeshvariOmkar L PatkarAnuj SehgalStephen J BushKim M SummersClare PridansKatharine M IrvinePublished in: Journal of immunology (Baltimore, Md. : 1950) (2021)
The laboratory rat continues to be the model of choice for many studies of physiology, behavior, and complex human diseases. Cells of the mononuclear phagocyte system (MPS; monocytes, macrophages, and dendritic cells) are abundant residents in every tissue in the body and regulate postnatal development, homeostasis, and innate and acquired immunity. Recruitment and proliferation of MPS cells is an essential component of both initiation and resolution of inflammation. The large majority of current knowledge of MPS biology is derived from studies of inbred mice, but advances in technology and resources have eliminated many of the advantages of the mouse as a model. In this article, we review the tools available and the current state of knowledge of development, homeostasis, regulation, and diversity within the MPS of the rat.
Keyphrases
- induced apoptosis
- dendritic cells
- oxidative stress
- immune response
- cell cycle arrest
- peripheral blood
- signaling pathway
- endothelial cells
- endoplasmic reticulum stress
- preterm infants
- cell death
- case control
- metabolic syndrome
- single molecule
- type diabetes
- pi k akt
- cell proliferation
- high fat diet induced
- decision making