Functional Impact of Genomic Complexity on the Transcriptome of Multiple Myeloma.

Bachisio ZicchedduMatteo Claudio Da Via Marta LionettiAkihiro MaedaSilvia MorlupiMatteo DugoKatia TodoertiStefania OlivaMattia D'AgostinoPaolo CorradiniCarl Ola Landgren Francesco IorioLoredana PettineAlessandra PompaMartina ManzoniLuca BaldiniAntonino NeriFrancesco Maura Niccolo' Bolli

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)

The multiple myeloma genomic architecture and transcriptome have a strict connection, led by CNAs and CRs. Gene mutations impacted especially with HS-mutations of oncogenes and biallelic tumor suppressor gene inactivation. Finally, a comprehensive geno-transcriptomic analysis allows the identification of specific deregulated pathways and candidate biomarkers for personalized treatments in multiple myeloma.

Keyphrases

multiple myeloma
copy number
genome wide
rna seq
single cell
gene expression
intellectual disability
autism spectrum disorder
transcription factor