Ferulic Acid Alleviates Atherosclerotic Plaques by Inhibiting VSMC Proliferation Through the NO/p21 Signaling pathway.
Xiaoyun WuZiwei HuJunjie ZhouJin LiuPing RenXi HuangPublished in: Journal of cardiovascular translational research (2022)
The benefits and risks of inhibiting the proliferation and migration of vascular smooth muscle cells (VSMCs) in atherosclerosis (AS) remain a subject of debate. In this study, we investigated the effect of ferulic acid (FA) on the proliferation and migration of VSMCs induced by platelet-derived growth factor (PDGF) and the associated mechanism and used ApoE<sup>-/-</sup> mice to study whether the effect of FA on VSMC proliferation and migration is beneficial in alleviating AS plaques. It was found that FA not only reduced blood lipid levels but also promoted the production of nitric oxide (NO) by MOVAS cells through the endothelial nitric oxide synthase (eNOS) pathway, inhibited the migration and proliferation of VSMCs induced by PDGF, promoted the expression of p21 in VSMCs, and exerted a therapeutic effect against AS.
Keyphrases
- vascular smooth muscle cells
- signaling pathway
- nitric oxide synthase
- nitric oxide
- angiotensin ii
- growth factor
- induced apoptosis
- pi k akt
- cardiovascular disease
- poor prognosis
- epithelial mesenchymal transition
- cell cycle arrest
- metabolic syndrome
- oxidative stress
- smooth muscle
- adipose tissue
- type diabetes
- insulin resistance
- skeletal muscle
- cell proliferation
- human health
- risk assessment
- mass spectrometry