HPV infection related immune infiltration gene associated therapeutic strategy and clinical outcome in HNSCC.
Hao ZengXindi SongJianrui JiLinyan ChenQimeng LiaoXue-Lei MaPublished in: BMC cancer (2020)
The eight hub genes we found presented with a stable co-expression in immune cell infiltration of HPV + ve HNSCC population. The co-expression of hub genes related to an immune microenvironment featuring an increase in immune cells but high degree of immune dysfunction status. Patients with high hub gene expression had a better response to ICB treatment, bleomycin and methotrexate. The co-expression of hub genes may be related to immune infiltration status in patients. The concrete molecular mechanism of hub genes function demands further exploration.
Keyphrases
- bioinformatics analysis
- poor prognosis
- genome wide
- network analysis
- gene expression
- genome wide identification
- end stage renal disease
- dna methylation
- ejection fraction
- chronic kidney disease
- binding protein
- newly diagnosed
- long non coding rna
- transcription factor
- copy number
- peritoneal dialysis
- patient reported outcomes
- smoking cessation
- drug induced
- cervical cancer screening