Central Nervous System Metastasis in Patients with HER2-Positive Metastatic Breast Cancer: Patient Characteristics, Treatment, and Survival from SystHERs.

Sara A HurvitzJoyce O'ShaughnessyGinny MasonDenise A YardleyMohammad JahanzebAdam BrufskyHope S RugoSandra M SwainPeter A KaufmanDebu TripathyLaura ChuHaocheng LiVincent AntaoMelody Cobleigh

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2018)

Despite advances in HER2-targeted treatments, patients with CNS metastasis continue to have a poor prognosis and impaired quality of life. Observation of CNS metastasis appears to influence HER2-targeted treatment choice.

Keyphrases

poor prognosis
metastatic breast cancer
long non coding rna
blood brain barrier
cancer therapy
case report
drug delivery
combination therapy