The Complex Association between COPD and COVID-19.
Nikhil T AwatadePeter A B WarkAndrew S L ChanS M Abdullah Al MamunNurul Yaqeen Mohd EsaKazuto MatsunagaChin Kook RheePhilip Michael HansbroSukhwinder Singh Sohalnull On Behalf Of The Asian Pacific Society Of Respirology Apsr Copd AssemblyPublished in: Journal of clinical medicine (2023)
Chronic obstructive pulmonary disease (COPD) is significant cause of morbidity and mortality worldwide. There is mounting evidence suggesting that COPD patients are at increased risk of severe COVID-19 outcomes; however, it remains unclear whether they are more susceptible to acquiring SARS-CoV-2 infection. In this comprehensive review, we aim to provide an up-to-date perspective of the intricate relationship between COPD and COVID-19. We conducted a thorough review of the literature to examine the evidence regarding the susceptibility of COPD patients to COVID-19 infection and the severity of their disease outcomes. While most studies have found that pre-existing COPD is associated with worse COVID-19 outcomes, some have yielded conflicting results. We also discuss confounding factors such as cigarette smoking, inhaled corticosteroids, and socioeconomic and genetic factors that may influence this association. Furthermore, we review acute COVID-19 management, treatment, rehabilitation, and recovery in COPD patients and how public health measures impact their care. In conclusion, while the association between COPD and COVID-19 is complex and requires further investigation, this review highlights the need for careful management of COPD patients during the pandemic to minimize the risk of severe COVID-19 outcomes.
Keyphrases
- chronic obstructive pulmonary disease
- coronavirus disease
- sars cov
- lung function
- end stage renal disease
- public health
- ejection fraction
- healthcare
- chronic kidney disease
- prognostic factors
- cystic fibrosis
- palliative care
- respiratory syndrome coronavirus
- dna methylation
- pain management
- intensive care unit
- insulin resistance
- skeletal muscle
- replacement therapy
- weight loss
- patient reported outcomes
- global health
- respiratory failure