The Dysfunctional Scenario of the Major Components Responsible for Myocardial Calcium Balance in Heart Failure Induced by Aortic Stenosis.
Vitor Loureiro da SilvaSérgio Luiz Borges de SouzaGustavo Augusto Ferreira MotaDijon Henrique Salomé de CamposAlexandre Barroso MeloDanielle Fernandes VileigasPaula Grippa Sant'AnaPriscila Murucci CoelhoSilméia Garcia Zanati BazanAndré Soares LeopoldoAntônio Carlos CicognaPublished in: Arquivos brasileiros de cardiologia (2022)
Systolic and diastolic heart failure due to supravalvular aortic stenosis was paralleled by impairment of cellular Ca2+ influx and inhibition of sarcoplasmic reticulum Ca2+ reuptake due to LTCC and SERCA2a dysfunction, as well as changes in Ca2+ handling and expression of the major proteins responsible for cellular Ca2+ homeostasis.
Keyphrases
- aortic stenosis
- left ventricular
- heart failure
- aortic valve replacement
- ejection fraction
- transcatheter aortic valve implantation
- transcatheter aortic valve replacement
- cardiac resynchronization therapy
- aortic valve
- protein kinase
- oxidative stress
- blood pressure
- coronary artery disease
- poor prognosis
- acute heart failure
- atrial fibrillation