Preoperative hypofractionated radiotherapy for soft tissue sarcomas: a systematic review.
Siyer RoohaniFelix EhretMarta KobusAnne FlörckenSven MärdianJana Käthe StrieflerDaniel RauRobert ÖllingerArmin JaroschVolker BudachDavid KaulPublished in: Radiation oncology (London, England) (2022)
Retrospective data and phase II trials suggest preoperative HFRT to be a reasonable treatment modality for STS. Oncological outcomes and toxicity profiles were favorable. To date, our knowledge is mostly derived from phase II data. No randomized phase III trial comparing normofractionated and HFRT in STS has been published yet. Multiple ongoing phase II trials applying HFRT to investigate acute and late toxicity will hopefully bring forth valuable findings.
Keyphrases
- phase ii
- phase iii
- open label
- clinical trial
- placebo controlled
- double blind
- electronic health record
- soft tissue
- radiation therapy
- patients undergoing
- oxidative stress
- early stage
- big data
- liver failure
- study protocol
- rectal cancer
- locally advanced
- radiation induced
- respiratory failure
- cross sectional
- high grade
- prostate cancer
- artificial intelligence
- radical prostatectomy
- oxide nanoparticles
- adipose tissue
- machine learning
- squamous cell carcinoma
- aortic dissection
- data analysis
- systematic review
- meta analyses