Viscoelastic haemostatic assays and fibrinogen in paediatric acute traumatic coagulopathy: A comprehensive review.
Sharon MaconachieMelanie JansenEmma CottleJohn RoyBryony RossJames WinearlsShane GeorgePublished in: Emergency medicine Australasia : EMA (2020)
The early identification of hypo-fibrinogenemia and acute traumatic coagulopathy in paediatric trauma using VHA testing and subsequent early fibrinogen replacement with a concentrated off the shelf product is an attractive treatment option. However, there is currently insufficient high-level evidence to support the use of fibrinogen concentrate over cryoprecipitate in the paediatric trauma population. Pilot studies currently under way will go some way to addressing this important knowledge gap, and facilitate the design of larger definitive multi-centre randomised trials.
Keyphrases
- liver failure
- intensive care unit
- spinal cord injury
- emergency department
- respiratory failure
- clinical trial
- aortic dissection
- study protocol
- drug induced
- healthcare
- high throughput
- randomized controlled trial
- hepatitis b virus
- replacement therapy
- extracorporeal membrane oxygenation
- combination therapy
- mass spectrometry
- radiation therapy
- high resolution