Differential Responsiveness of Monocyte and Macrophage Subsets to Interferon.

Shuhong HanHaoyang ZhuangPui Y LeeMingjia LiLijun YangPeter A NigrovicWestley H Reeves

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2019)

This study revealed that the relative abundance of different monocyte/macrophage subsets helps determine the magnitude of the IFN signature. Responsiveness to IFNα signaling reflects differences in IFNAR expression in classic (high IFNAR) compared to nonclassic (low IFNAR) monocyte/macrophages. Thus, the IFN signature depends on both type I IFN production and the responsiveness of monocyte/macrophages to IFNAR signaling.

Keyphrases

dendritic cells
immune response
peripheral blood
adipose tissue
poor prognosis
endothelial cells
single cell
antibiotic resistance genes
wastewater treatment