Mesenchymal stem cells alleviate the early brain injury of subarachnoid hemorrhage partly by suppression of Notch1-dependent neuroinflammation: involvement of Botch.
Wenchao LiuRan LiJian YinShenquan GuoYunchang ChenHaiyan FanGancheng LiZhenjun LiXifeng LiXin ZhangXuying HeChuan-Zhi DuanPublished in: Journal of neuroinflammation (2019)
BMSCs treatment alleviated neurobehavioral impairments and the inflammatory response in EBI after SAH; these effects may be attributed to Botch upregulation in brain tissue, which subsequently inhibited the Notch1 signaling pathway.
Keyphrases
- brain injury
- subarachnoid hemorrhage
- cerebral ischemia
- inflammatory response
- signaling pathway
- mesenchymal stem cells
- cell proliferation
- lipopolysaccharide induced
- lps induced
- pi k akt
- umbilical cord
- poor prognosis
- bone marrow
- toll like receptor
- blood brain barrier
- resting state
- stem cells
- white matter
- cognitive impairment
- induced apoptosis
- replacement therapy
- combination therapy
- oxidative stress
- endoplasmic reticulum stress