Gut Lactobacillus and Probiotics Lactobacillus lactis/rhamnosis Ameliorate Liver Fibrosis in Prevention and Treatment.
Sung Min WonNa Young LeeKi-Kwang OhHaripriya GuptaSatya Priya SharmaKyung Hwan KimByoung Kook KimHyun Chae JoungJin Ju JeongRaja GanesanSang Hak HanSang Jun YoonDong Joon KimKi Tae SukPublished in: Journal of microbiology (Seoul, Korea) (2023)
The progression and exacerbation of liver fibrosis are closely related to the gut microbiome. It is hypothesized that some probiotics may slow the progression of liver fibrosis. In human stool analysis [healthy group (n = 44) and cirrhosis group (n = 18)], difference in Lactobacillus genus between healthy group and cirrhosis group was observed. Based on human data, preventive and therapeutic effect of probiotics Lactobacillus lactis and L. rhamnosus was evaluated by using four mice fibrosis models. L. lactis and L. rhamnosus were supplied to 3,5-diethoxycarbonyl-1,4-dihydrocollidine or carbon tetrachloride-induced liver fibrosis C57BL/6 mouse model. Serum biochemical measurements, tissue staining, and mRNA expression in the liver were evaluated. The microbiome was analyzed in mouse cecal contents. In the mouse model, the effects of Lactobacillus in preventing and treating liver fibrosis were different for each microbe species. In case of L. lactis, all models showed preventive and therapeutic effects against liver fibrosis. In microbiome analysis in mouse models administered Lactobacillus, migration and changes in the ratio and composition of the gut microbial community were confirmed. L. lactis and L. rhamnosus showed preventive and therapeutic effects on the progression of liver fibrosis, suggesting that Lactobacillus intake may be a useful strategy for prevention and treatment.
Keyphrases
- liver fibrosis
- mouse model
- microbial community
- endothelial cells
- lactic acid
- chronic obstructive pulmonary disease
- induced pluripotent stem cells
- drug induced
- extracorporeal membrane oxygenation
- oxidative stress
- deep learning
- electronic health record
- high fat diet induced
- artificial intelligence
- liver injury
- data analysis
- weight gain
- flow cytometry