Fibrinogen levels in severe trauma: A preliminary comparison of Clauss Fibrinogen, ROTEM Sigma, ROTEM Delta and TEG 6s assays from the FEISTY pilot randomised clinical trial.

Travis AutyJames McCulloughIan Hughes Jonathon P Fanning Sarah Czuchwicki James Winearls

Published in: Emergency medicine Australasia : EMA (2024)

The present study revealed acceptable agreement between four different assays measuring functional fibrinogen, with current- and previous-generation ROTEM® machines (Sigma, Delta) performing similarly measuring functional fibrinogen via FIBTEM assay. This suggests that haemostatic resuscitation algorithms designed for the ROTEM® Delta can be applied to the ROTEM® Sigma to guide fibrinogen replacement.

Keyphrases

clinical trial
high throughput
study protocol
open label
machine learning
cardiac arrest
double blind
randomized controlled trial
early onset