The greater impact of PNPLA3 polymorphism on liver-related events in Japanese non-alcoholic fatty liver disease patients: A multicentre cohort study.
Yuya SekoKanji YamaguchiToshihide ShimaMichihiro IwakiHirokazu TakahashiMiwa KawanakaSaiyu TanakaYasuhide MitsumotoMasato YonedaAtsushi NakajimaOla FjellströmJenny E BlauBjörn CarlssonTakeshi OkanoueYoshito ItohPublished in: Liver international : official journal of the International Association for the Study of the Liver (2023)
In Japanese individuals, the main cause of death from NAFLD is liver-related death. The greater risk of liver-related events incurred by PNPLA3 G allele was shown in Japan. Risk stratification for NAFLD in Japan is best accomplished by integrating PNPLA3 with the FIB-4 index.