Immunostimulatory Cancer-Associated Fibroblast Subpopulations Can Predict Immunotherapy Response in Head and Neck Cancer.
Aleksandar ObradovicDiana GravesMichael KorrerYu WangSohini RoyAbdullah B NaveedYaomin XuAdam LuginbuhlJoseph CurryMichael K GibsonKamran IdreesPaula HurleyPeng JiangX Shirley LiuRavindra UppaluriCharles G DrakeAndrea CalifanoYoung J KimPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
Our findings demonstrate the functional importance of distinct HNCAF subsets in modulating the immunoregulatory milieu of human HNSCC. In addition, we have identified clinically actionable HNCAF subtypes that can be used as a biomarker of response and resistance in future clinical trials.