Staphylococcus aureus biofilm exoproteins are cytotoxic to human nasal epithelial barrier in chronic rhinosinusitis.
Beula Subashini PanchatcharamClare M CooksleyMahnaz RamezanpourRajan Sundaresan VediappanAhmed BassiouniPeter J WormaldAlkis J PsaltisSarah VreugdePublished in: International forum of allergy & rhinology (2020)
S aureus biofilm exoproteins disrupt the mucosal barrier structure in a time- and dose-dependent manner and are toxic. Damage to the mucosal barrier by S aureus biofilm exoproteins may play a major role in CRS etiopathogenesis.