A comprehensive assessment of multi-system responses to a renal inoculation of uropathogenic E. coli in swine.
Mohamad Hakam TibaBrendan M McCrackenRobert P DicksonJean A NemzekCarmen I ColmeneroDanielle C LeanderThomas L FlottRodney C DanielsKristine E KonopkaJ Scott VanEppsKathleen A StringerKevin R WardPublished in: PloS one (2020)
We demonstrate a versatile, multi-system, longitudinal, swine model of infection that could be used to further our understanding of the mechanisms that underlie infection-induced multi-organ dysfunction and failure, optimize resuscitation protocols and test therapeutic interventions. Such a model could improve translation of findings from the bench to the bedside, circumventing a significant obstacle in sepsis research.