Predictors of Loss of Functional Independence in Parkinson's Disease: Results from the COPPADIS Cohort at 2-Year Follow-Up and Comparison with a Control Group.
Diego Santos GarcíaTeresa de Deus FonticobaCarlos Cores BartoloméLucía Naya RíosLucía García RocaCristina Martínez MiróHector CanfieldSilvia JesúsMiquel AguilarPau PastorMarina CosgayaJuan García CaldenteyNuria CaballolInés LegardaJorge Hernández VaraIria CaboLydia López ManzanaresIsabel González AramburuAsunción AvilaVictor Gomez-MayordomoVíctor NogueiraVíctor PuenteJulio DotorCarmen BorruéBerta Solano VilaMaría Álvarez SaucoLydia VelaSonia EscalanteEsther Cubo-DelgadoFrancisco Carrillo PadillaMartínez-Castrillo Juan CarlosPilar Sánchez AlonsoMaria G Alonso LosadaN López ArizteguiItziar GastónJaime KulisevskyMarta BlázquezManuel SeijoJavier Rúiz MartínezCaridad ValeroMónica KurtisOriol De FabreguesJessica González ArduraRuben Alonso RedondoCarlos OrdásLuis M López DíazDarrian McAfeePablo Martínez-MartínPablo Mirnull Coppadis Study GroupPublished in: Diagnostics (Basel, Switzerland) (2021)
In conclusion, autonomy for ADL worsens in PD patients compared to controls. Cognitive impairment, gait problems, fatigue, depressive symptoms, more advanced disease, and a non-tremor phenotype are independent predictors of FD in the short-term.