Altered DNA methylation pattern characterizes the peripheral immune cells of patients with autoimmune hepatitis.
Kalliopi ZachouPinelopi ArvanitiAggeliki LyberopoulouEirini SevdaliMatthaios SpeletasMaria IoannouGeorge K KoukoulisYves RenaudineauGeorgios N DalekosPublished in: Liver international : official journal of the International Association for the Study of the Liver (2022)
Altered TET1 and DNMT3A expressions, characterize peripheral lymphocytes in AIH. DNMT3A was associated with disease activity and decreased following remission. Gene DNA methylation modifications affect immunological pathways that may play an important role in AIH pathogenesis.
Keyphrases
- dna methylation
- disease activity
- genome wide
- systemic lupus erythematosus
- rheumatoid arthritis
- rheumatoid arthritis patients
- ankylosing spondylitis
- copy number
- gene expression
- juvenile idiopathic arthritis
- chemotherapy induced
- multiple sclerosis
- drug induced
- genome wide identification
- transcription factor
- genome wide analysis