Metformin partially reverses the inhibitory effect of co-culture with ER-/PR-/HER2+ breast cancer cells on biomarkers of monocyte antitumor activity.

Zoheir DahmaniLynda Addou-KloucheFlorence GizardSara DahouAida MessaoudNihel Chahinez DjebriMahmoud Idris BenaisstiMeriem MostefaouiHadjer TerbecheWafa NouariMarwa MilianiGérard LefrancAnne FernandezNed J LambMourad Aribi

Published in: PloS one (2020)

Our results show that the biomarkers of phenotypic functional activities of MOs are modified after co-culturing with primary human breast cancer cells. Treatment of co-cultures with MET resulted in increased release of antitumor cytokine IFN-γ and ifCa2+, and increased cell necrosis during breast cancer cells-MOs crosstalk.

Keyphrases

breast cancer cells
endothelial cells
dendritic cells
quantum dots
room temperature
single cell
reduced graphene oxide
immune response
stem cells
tyrosine kinase
induced pluripotent stem cells
peripheral blood
transition metal
pluripotent stem cells
smoking cessation