Intense prostate-specific membrane antigen receptor expression in coronary artery pypass graft scar tissue: A potential molecular imaging pitfall.
Akram N Al-IbraheemAhmed Saad AbdlkadirNabeela Al-HajajAysar KhalafSamer SalahPublished in: Acta radiologica open (2024)
68 Gallium-PSMA positron emission tomography/computer tomography has been utilized recently for the diagnosis and staging of prostate cancer. PSMA is a transmembrane protein that is expressed not only in the prostate gland but also in other tissues. While some pitfalls have been addressed, there are still uncertainties. Herein, we report a 79-year-old male with prostate cancer who underwent a PSMA scan after coronary artery bypass graft surgery, revealing disease progression and PSMA-avid foci at the surgical stitch sites. This report discusses the immunohistochemical and molecular imaging mechanisms underlying PSMA expression in surgical scar tissues, providing critical insights for optimizing radiologic reporting in such situations.
Keyphrases
- pet ct
- prostate cancer
- positron emission tomography
- coronary artery bypass
- pet imaging
- radical prostatectomy
- coronary artery
- computed tomography
- gene expression
- percutaneous coronary intervention
- poor prognosis
- minimally invasive
- binding protein
- magnetic resonance
- small molecule
- emergency department
- pulmonary hypertension
- human health
- wound healing
- surgical site infection