The diagnostic accuracy of human epididymis protein 4 (HE4) for discriminating between benign and malignant pelvic masses: a systematic review and meta-analysis.
Maria OlsenPien LofAnna StiekemaDaan van den BroekErica A WilthagenPatrick M BossuytChristianne A R LokPublished in: Acta obstetricia et gynecologica Scandinavica (2021)
HE4 had higher specificity and similar sensitivity compared with CA125. At high prevalence, PPV was also higher for HE4, but at low prevalence, it had a similar NPV to CA125. The field would benefit from studies conducted in general settings.