Prospective assessment of the predictive value of the BRCA1 gene status in sarcoma patients treated with trabectedin: an updated analysis of the EORTC 62091 trial.

Antoine ItalianoNathan TouatiSaskia LitièreFrançoise CollinPhilippe PourquierAlessandro Gronchi

Published in: Cancer medicine (2018)

We describe the predictive value of BRCA1 gene status on trabectedin efficacy and found no correlation despite the mechanisms of action of this drug that rely on DNA repair systems.

Keyphrases

dna repair
dna damage
copy number
genome wide
study protocol
genome wide identification
dna damage response
clinical trial
phase iii
randomized controlled trial
emergency department
phase ii
open label