Pan-cancer multi-omics analyses reveal crosstalk between the Hippo and immune signaling pathways in the tumor microenvironment.
Chengyu WangTong ZhuZhangxiang ZhaoBo ChenTingting ChenQi DongMingyue LiuShuping ZhuangFan YangYaoyao LiuMin YangYunyan GuHaihai LiangPublished in: FEBS letters (2021)
The Hippo signaling pathway is critical for carcinogenesis. However, the roles of the Hippo signaling pathway in the tumor immune microenvironment have been rarely investigated. This study systematically analyzed the relationship between the Hippo signaling pathway and immune cell infiltration across 32 cancer types. Both bioinformatics analyses and biological experiments revealed that the downstream effector of Hippo signaling YAP1 might inhibit CD8+ T cell infiltration by upregulating the expression of the transcription factor CREB1 in uterine corpus endometrial carcinoma. In addition, esophageal carcinoma (ESCA) patients were classified into three subtypes based on the Hippo-immune gene panel. The subtypes of ESCA had distinct characteristics in immune cell infiltration, immune pathways, and prognosis. Thus, this study also reveals a new classification of the immune subtypes with prognostic characteristics in ESCA.
Keyphrases
- signaling pathway
- pi k akt
- transcription factor
- epithelial mesenchymal transition
- papillary thyroid
- single cell
- stem cells
- induced apoptosis
- ejection fraction
- genome wide
- poor prognosis
- newly diagnosed
- squamous cell
- cell proliferation
- gene expression
- deep learning
- young adults
- dna methylation
- chronic kidney disease
- atomic force microscopy
- oxidative stress
- dna binding
- high resolution
- high speed
- patient reported
- single molecule
- genome wide identification