Altered expression of the kisspeptin/KISS1R and neurokinin B/NK3R systems in mural granulosa and cumulus cells of patients with polycystic ovarian syndrome.

Victor BlascoFrancisco M PintoAinhoa Fernández-AtuchaNicolás PradosManuel Tena-SempereManuel Fernández-SánchezLuz Candenas

Published in: Journal of assisted reproduction and genetics (2018)

The NKB/NK3R and KISS1/KISS1R systems are dysregulated in MGCs and CCs of PCOS women. The lower expression of these systems in GCs could contribute to the abnormal follicle development and defective ovulation that characterize the pathogenesis of PCOS.

Keyphrases

polycystic ovary syndrome
insulin resistance
poor prognosis
induced apoptosis
nk cells
cell cycle arrest
metabolic syndrome
long non coding rna
oxidative stress
pregnant women
cell proliferation
cervical cancer screening