Multimodal Imaging-Assisted Intravascular Theranostic Photoactivation on Atherosclerotic Plaque.
Jin Hyuk KimJoon Woo SongYeon Hoon KimHyun Jung KimRyeong Hyun KimYe Hee ParkHyeong Soo NamDong Oh KangHongki YooKyeongsoon ParkJin Won KimPublished in: Circulation research (2024)
Optical coherence tomography-near-infrared fluorescence imaging-guided macrophage dectin-1-targetable photoactivation could induce the transition of macrophage/lipid-rich plaques into collagen-rich lesions through autophagy-mediated inflammation resolution and TGF-β-dependent fibrotic replacement. This novel strategy offers a new opportunity for the catheter-based theranostic strategy.
Keyphrases
- fluorescence imaging
- photodynamic therapy
- oxidative stress
- optical coherence tomography
- adipose tissue
- cell death
- coronary artery
- endoplasmic reticulum stress
- high resolution
- systemic sclerosis
- coronary artery disease
- transforming growth factor
- diabetic retinopathy
- idiopathic pulmonary fibrosis
- fatty acid
- tissue engineering
- iron oxide