High PD-L1 expression indicates poor prognosis of HIV-infected patients with non-small cell lung cancer.
Yusuke OkumaTsunekazu HishimaJumpei KashimaSadamu HommaPublished in: Cancer immunology, immunotherapy : CII (2017)
High PD-L1 expression in tumor tissue was associated with poor prognosis in HIV-infected NSCLC patients but not in non-HIV-infected NSCLC patients. These results suggest that antitumor immunity by PD-1/PD-L1 axis might be suppressed more in HIV-infected NSCLC patients as compared to their non-HIV-infected counterparts.
Keyphrases
- hiv infected
- poor prognosis
- antiretroviral therapy
- end stage renal disease
- newly diagnosed
- small cell lung cancer
- hiv infected patients
- long non coding rna
- peritoneal dialysis
- prognostic factors
- human immunodeficiency virus
- advanced non small cell lung cancer
- hepatitis c virus
- patient reported outcomes
- epidermal growth factor receptor
- brain metastases