A novel temporal identity window generates alternating Eve+/Nkx6+ motor neuron subtypes in a single progenitor lineage.

Austin SerokaRita M YazejianSen-Lin LaiChris Q Doe

Published in: Neural development (2020)

We show that one neuroblast lineage generates interleaved cardinal motor neurons fates; that the Kr/Pdm TTFs form a novel temporal identity window that promotes expression of Nkx6; and that the Kr/Pdm > Nkx6 pathway is necessary and sufficient to promote VO motor neuron targeting to the correct ventral muscle group.

Keyphrases

spinal cord
cell fate
poor prognosis
single cell
skeletal muscle
cancer therapy
deep brain stimulation
binding protein
long non coding rna
drug delivery