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Digoxin treatment does not reinduce radioiodine uptake in radioiodine refractory non-medullary thyroid carcinoma.

Pepijn van HoutenJames NagarajahJanneke E W WalravenMartin JaegerAdriana C H van Engen-van GrunsvenJohannes W SmitRomana T Netea-Maier
Published in: European thyroid journal (2024)
Contrary to results from preclinical trials, in this trial, 3 weeks of digoxin treatment did not reinduce RAI uptake in patients with NMTC. This highlights essential challenges regarding the approach toward optimization of studies aimed to restore the RAI uptake and its therapeutic efficacy through drug repurposing.
Keyphrases
  • randomized controlled trial
  • emergency department
  • study protocol
  • mesenchymal stem cells
  • open label
  • electronic health record