Resilience and resistance to the accumulation of amyloid plaques and neurofibrillary tangles in centenarians: An age-continuous perspective.

Meng ZhangAndrea B GanzSusan RohdeAnnemieke J M RozemullerNetherlands Brain BankMarcel J T ReindersPhilip ScheltensMarc HulsmanJeroen J M HoozemansHenne Holstege

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2022)

Cognitively healthy elderly have AD neuropathology levels similar to AD patients. AD neuropathology loads do not correlate with cognitive performance in centenarians. Some centenarians are resilient to the highest levels of AD neuropathology.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
cognitive decline
social support
depressive symptoms
community dwelling