eIF2α phosphorylation is required to prevent hepatocyte death and liver fibrosis in mice challenged with a high fructose diet.
Woo-Gyun ChoiJaeseok HanJi-Hyeon KimMi-Jeong KimJae-Woo ParkBenbo SongHee-Jeong ChaHye-Seon ChoiHun-Taeg ChungIn-Kyu LeeTae-Sik ParkMaria HatzoglouHueng-Sik ChoiHyun Ju YooRandal J KaufmanSung Hoon BackPublished in: Nutrition & metabolism (2017)
Our findings suggest that eIF2α phosphorylation maintains NADPH and GSH levels and controls the expression of ROS-defense genes, thereby protecting hepatocytes from oxidative stresses induced by fructose metabolism.
Keyphrases
- liver fibrosis
- reactive oxygen species
- liver injury
- protein kinase
- poor prognosis
- physical activity
- weight loss
- dna damage
- drug induced
- genome wide
- cell death
- high fat diet induced
- fluorescent probe
- binding protein
- type diabetes
- bioinformatics analysis
- adipose tissue
- insulin resistance
- wild type
- innate immune
- oxidative stress
- genome wide identification
- genome wide analysis