Systemic and Oligo-Acquired Resistance to PD-(L)1 Blockade in Lung Cancer.
Adam J SchoenfeldHira A RizviDanish MemonNarek ShaverdianMatthew J BottJennifer L SauterC Jillian TsaiJayon LihmDavid HoyosAndrew J PlodkowskiRocio Perez-JohnstonPeter SawanJacklynn V EggerBenjamin D GreenbaumAndreas RimnerGregory J RielyCharles M RudinValerie W RuschDaniel R GomezMatthew D HellmannPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
OligoAR is a common and distinct pattern of acquired resistance to PD-(L)1 blockade compared with sAR. OligoAR is associated with improved post-progression survival and some cases can be effectively managed with local therapies with durable benefit.
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