Longitudinal Progression of Magnetic Resonance Imaging Markers and Cognition in Dutch-Type Hereditary Cerebral Amyloid Angiopathy.
Suzanne E van DijkJeroen van der GrondJessie LakAnnette van den Berg-HuysmansGerda LabadieGisela M TerwindtMarieke J H WermerMahmut Edip GurolMark A van BuchemSteven M GreenbergSanneke van RoodenPublished in: Stroke (2022)
Our findings indicate that in the presymptomatic phase of D-CAA, cerebrovascular reactivity measured by the blood-oxygen-level-dependent amplitude and time to peak to visual stimulation progressively worsens and can thus be regarded as a disease progression marker. In the symptomatic phase, the most salient marker of progression appears to be recurrent intracerebral hemorrhage.