Preliminary evidence for the efficacy of single-session transcranial direct current stimulation to the ventrolateral prefrontal cortex for reducing subclinical paranoia in healthy individuals.

In both clinical and subclinical populations, paranoia is related to distress and poorer functional outcomes. Paranoia has been linked to overactivation of the amygdala, a brain region responsible for detecting salience and threat, and reduced activation of the ventrolateral prefrontal cortex (VLPFC), a region thought to modulate and regulate amygdala activity. In this study, transcranial direct current stimulation (tDCS) of the VLPFC reduced self-reported paranoia in healthy undergraduate students. tDCS may be a promising intervention for reducing paranoia in subclinical and clinical populations. Effects were relatively small and require replication with larger subclinical samples and with clinical samples.