Genome-wide studies reveal the essential and opposite roles of ARID1A in controlling human cardiogenesis and neurogenesis from pluripotent stem cells.

Juli LiuSheng LiuHongyu GaoLei HanXiaona ChuYi ShengWeinian ShouYue WangYunlong LiuJun WanLei Yang

Published in: Genome biology (2020)

We uncover the opposite roles by ARID1A to govern both early cardiac and neural development from pluripotent stem cells. Global chromatin accessibility on cardiogenic genes is dependent on ARID1A, whereas transcriptional activity of neurogenic genes is under control by ARID1A, possibly through ARID1A-REST/NRSF interaction.

Keyphrases

pluripotent stem cells
genome wide
dna methylation
gene expression
copy number
transcription factor
spinal cord injury
single cell
genome wide identification
blood brain barrier
genome wide analysis
induced pluripotent stem cells
heat stress