Expression profiling of ileal mucosa in asthma reveals upregulation of innate immunity and genes characteristic of Paneth and goblet cells.

Jan Krzysztof NowakMarzena DworackaNazgul GubajArystan DossimovZhumabek DossimovJarosław Walkowiak

Published in: Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology (2021)

Ileal mucosa in asthma exhibits a specific transcriptomic profile, which includes the overexpression of innate immune genes, mostly characteristic of Paneth and goblet cells, in addition to other changes that may resemble Crohn's disease.

Keyphrases

induced apoptosis
genome wide
cell cycle arrest
chronic obstructive pulmonary disease
innate immune
cell proliferation
lung function
signaling pathway
cell death
endoplasmic reticulum stress
single cell
oxidative stress
poor prognosis
allergic rhinitis
genome wide analysis
pi k akt