Rethinking the transfusion pathway in myelodysplastic syndromes: Study protocol for a novel randomized feasibility n-of-1 trial of weekly-interval red cell transfusion in myelodysplastic syndromes.
Allison MoErica WoodJake ShorttAndrew CharltonDorothea EversMarlijn HoeksElizabeth PritchardJames DalyCarol HodgsonStephen OpatDavid BowenJohn ReynoldsLe Thi Phuong ThaoSimon J StanworthZoe K McQuiltenPublished in: Transfusion (2024)
This pilot trial evaluates a novel personalized transfusion approach of weekly matched RBC transfusion and challenges the dogma of current routine pre-transfusion matching practice. Findings on study feasibility, HRQoL, and physical functional outcomes and the qualitative substudy will inform the design of a larger definitive trial powered for clinical outcomes.
Keyphrases
- cardiac surgery
- phase iii
- sickle cell disease
- phase ii
- study protocol
- clinical trial
- open label
- healthcare
- acute kidney injury
- physical activity
- primary care
- systematic review
- mental health
- stem cells
- single cell
- randomized controlled trial
- radiation therapy
- squamous cell carcinoma
- clinical practice
- quality improvement
- locally advanced