Will carbon nanotube/nanofiber bring new hope for the treatment of heart damage? A systematic review.
Mahsa Tashakori-MiyanroudiAtousa JanzadehAlexander SeifalianNahid AboutalebYaser AziziFatemeh RamezaniPublished in: Nanomedicine (London, England) (2023)
Aim: Despite scientific advances, the number of cardiovascular patients is increasing worldwide. To protect damaged cardiomyocytes from further harm, novel and safer approaches are needed to help regeneration and prevent fibrosis. Methods: In this study, we performed a systematic review of in vitro and preclinical studies of carbon nanotubes (CNTs) and carbon nanofibers (CNFs) for help to treat heart damage. Conclusion: CNTs/CNFs in hydrogels cause higher conductivity, and the in case of alignment this increase is more than the random state. CNTs/CNFs can improve structural specification of the hydrogel for cardiac cell proliferation and enhance expression of genes associated with final differentiation of various stem cells to cardiac cells.
Keyphrases
- carbon nanotubes
- stem cells
- cell proliferation
- end stage renal disease
- heart failure
- drug delivery
- oxidative stress
- newly diagnosed
- ejection fraction
- induced apoptosis
- poor prognosis
- left ventricular
- chronic kidney disease
- wound healing
- cell therapy
- atrial fibrillation
- hyaluronic acid
- cell cycle
- prognostic factors
- peritoneal dialysis
- cell cycle arrest
- patient reported outcomes
- binding protein
- tissue engineering
- replacement therapy
- case control
- endoplasmic reticulum stress
- smoking cessation
- endothelial cells
- liver fibrosis
- neural network