Development and validation of a prediction model for tocilizumab failure in hospitalized patients with SARS-CoV-2 infection.

Cristina MussiniAlessandro Cozzi-LepriMarianna MenozziMarianna MeschiariErica FranceschiniJovana MilicLucio BrugioniAntonello PietrangeloMassimo GirardisAndrea CossarizzaRoberto TonelliEnrico CliniMarco MassariMichele BartolettiAnna FerrariAnna Maria CattelanPaola ZuccalàMiriam LichtnerRoberto RossottiEnrico GirardiEmanuele NicastriMassimo PuotiAndrea AntinoriPierluigi VialeGiovanni Guaraldi

Published in: PloS one (2021)

Our score could assist clinicians in identifying, early after tocilizumab administration, patients who are likely to progress to mechanical ventilation or death, so that they could be selected for eventual rescue therapies.

Keyphrases

mechanical ventilation
rheumatoid arthritis
end stage renal disease
ejection fraction
intensive care unit
acute respiratory distress syndrome
chronic kidney disease
juvenile idiopathic arthritis
rheumatoid arthritis patients
peritoneal dialysis
palliative care
patient reported