A genome-wide search for pleiotropy in more than 100,000 harmonized longitudinal cognitive domain scores.
Moonil KangTing Fang Alvin AngSherral A DevineRichard ShervaShubhabrata MukherjeeEmily H TrittschuhLaura E GibbonsPhoebe ScollardMichael LeeSeo-Eun ChoiBrandon KlinedinstConnie NakanoLogan C DumitrescuAlaina DurantTimothy J HohmanMichael L CuccaroAndrew J SaykinWalter A KukullDavid A BennettLi-San WangRichard P MayeuxJonathan L HainesMargaret A Pericak-VanceGerard D SchellenbergPaul K CraneRhoda AuKathryn L LunettaJesse B MezLindsay A FarrerPublished in: Molecular neurodegeneration (2023)
Our results provide some insight into biological pathways underlying processes leading to domain-specific cognitive impairment and AD, as well as a conduit toward a syndrome-specific precision medicine approach to AD. Increasing the number of participants with harmonized cognitive domain scores will enhance the discovery of additional genetic factors of cognitive decline leading to AD and related dementias.