Reduced postprandial bone resorption and greater rise in GLP-1 in overweight and obese individuals after an α-glucosidase inhibitor: a double-blinded randomized crossover trial.
A KreitmanS H SchneiderL HaoY SchlusselN T BelloSue A ShapsesPublished in: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA (2021)
This study indicates that attenuating postprandial glycemic indices, with an α-GI, markedly decreases postprandial bone resorption and can be explained by the rise in GLP-1. Future studies should determine whether longer term α-GI use benefits bone health.
Keyphrases
- bone loss
- bone mineral density
- blood glucose
- phase iii
- open label
- double blind
- soft tissue
- placebo controlled
- healthcare
- phase ii
- public health
- bone regeneration
- type diabetes
- clinical trial
- study protocol
- postmenopausal women
- preterm infants
- randomized controlled trial
- metabolic syndrome
- body composition
- adipose tissue
- current status
- climate change
- glycemic control
- gestational age
- preterm birth