Selenomethionine Inhibited HADV-Induced Apoptosis Mediated by ROS through the JAK-STAT3 Signaling Pathway.
Chuqing LiXia LiuJiali LiJia LaiJingyao SuBing ZhuBuyun GaoYinghua LiMingqi ZhaoPublished in: Nutrients (2024)
Adenovirus (HAdV) can cause severe respiratory infections in children and immunocompromised patients. There is a lack of specific therapeutic drugs for HAdV infection, and the study of anti-adenoviral drugs has far-reaching clinical implications. Elemental selenium can play a specific role as an antioxidant in the human immune cycle by non-specifically binding to the amino acid methionine in body proteins. Methods: The antiviral mechanism of selenomethionine was explored by measuring cell membrane status, intracellular DNA status, cytokine secretion, mitochondrial membrane potential, and ROS production. Conclusions: Selenomethionine improved the regulation of ROS-mediated apoptosis by modulating the expression of Jak1/2, STAT3, and BCL-XL, which led to the inhibition of apoptosis. It is anticipated that selenomethionine will offer a new anti-adenoviral therapeutic alternative.
Keyphrases
- induced apoptosis
- oxidative stress
- signaling pathway
- endoplasmic reticulum stress
- cell death
- reactive oxygen species
- dna damage
- amino acid
- end stage renal disease
- chronic kidney disease
- poor prognosis
- ejection fraction
- newly diagnosed
- endothelial cells
- young adults
- epithelial mesenchymal transition
- peritoneal dialysis
- early onset
- circulating tumor
- prognostic factors
- drug induced
- cell free
- anti inflammatory
- intensive care unit
- nucleic acid
- climate change
- circulating tumor cells
- risk assessment
- patient reported