Eosinophil ETosis-Mediated Release of Galectin-10 in Eosinophilic Granulomatosis With Polyangiitis.

Mineyo Fukuchi Yosuke Kamide Shigeharu Ueki Yui MiyabeYasunori KonnoNobuyuki OkaHiroki TakeuchiSouichi KoyotaMakoto HirokawaTakechiyo YamadaRossana C N MeloPeter F WellerMasami Taniguchi

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2021)

Eosinophils infiltrating diseased tissues in EGPA undergo EETosis. Considering the exclusive expression and large pool of cytoplasmic galectin-10 in eosinophils, elevated serum galectin-10 levels in patients with EGPA might reflect the systemic occurrence of cytolytic EETosis.

Keyphrases

poor prognosis
risk assessment
gene expression
chronic rhinosinusitis