Separate signaling events control TCR downregulation and T cell activation in primary human T cells.
Lieve E H van der DonkLouis S AtesJet van der SpekLaura M TukkerTeunis B H GeijtenbeekJeroen W J van HeijstPublished in: Immunity, inflammation and disease (2020)
These data suggest that there is substantial redundancy in the contribution of individual tyrosine kinases to TCR downregulation in primary human T cells. Our results highlight that TCR downregulation and T cell activation are controlled by different signaling events and illustrate the need for further research to untangle these processes.