NLRX1 can counteract innate immune response induced by an external stimulus favoring HBV infection by competitive inhibition of MAVS-RLRs signaling in HepG2-NTCP cells.

Qian JiaoWenxiong XuXiaoyan GuoHuiyuan LiuBaolin LiaoXiang ZhuChuming ChenFangji YangLina WuChan XieLiang Peng

Published in: Science progress (2022)

NLRX1 can counteract innate immune response induced by an external stimuli favoring hepatitis B virus infection by competitive inhibition of MAVS-RLRs signaling in HepG2-NTCP cells. Inhibition of the MAVS-RLR-mediated signaling pathways leads to a decline in the expression levels of I-IFN and IL-6.

Keyphrases

immune response
induced apoptosis
cell cycle arrest
dendritic cells
signaling pathway
toll like receptor
endoplasmic reticulum stress
poor prognosis
hepatitis b virus
oxidative stress
pi k akt
long non coding rna
inflammatory response